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Understanding the effects of fentanyl, the drug fueling an epidemic in North Texas

And what to do if someone has an overdose.

Some of the latest victims of fentanyl poisoning are North Texas kids. Here's what to know about fentanyl, including signs of an overdose and how to stop it.

Fentanyl is a highly addictive opioid drug that kills hundreds of Texans every year, according to the Texas Department of Health and Human Services.

Doctors can prescribe fentanyl to treat severe pain after surgery or for late-stage cancer. Most recent cases of fentanyl overdose are happening with illicit fentanyl, according to the Centers for Disease Control and Prevention.

Fentanyl can be mixed into cocaine and methamphetamines, and can be found in nasal sprays or eye drops. It can also be mixed into counterfeit pills that look like other prescription opioids, according to the CDC. As a result, people can ingest fentanyl without knowing, leading to accidental poisoning and even death.

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Depending on a person’s weight and drug history, consuming even 2 milligrams of fentanyl can be fatal.

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How does fentanyl affect the brain and body?

Fentanyl is 50 times stronger than heroin and 100 times stronger than morphine, according to the CDC. Once consumed, it enters the brain quickly, making it highly addictive.

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Fentanyl activates two brain pathways that release dopamine, a chemical that can cause feelings of pleasure and euphoria, according to Colin Haile, a researcher at the University of Houston who led a team that developed a fentanyl vaccine.

Haile said fentanyl can also stimulate neurons in our brains that help control breathing. This can lead to symptoms like slow or weak breathing.

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Signs of fentanyl overdose include choking or gurgling sounds, falling asleep or losing consciousness, and cold or discolored skin, especially in the lips and nails, according to the CDC.

The CDC says it can be hard to tell whether a person is experiencing an overdose, but that if you aren’t sure, treat the situation like an overdose. Call 911 immediately and if available, administer naloxone, a life-saving medication that can reverse opioid-related overdoses if used in time. Narcan is one brand of prepackaged naloxone nasal spray.

In addition, the CDC recommends keeping the person awake and breathing, laying them on their side to avoid choking, and remaining with them until emergency assistance arrives.

Adithi Ramakrishnan is a science reporting fellow at The Dallas Morning News. Her fellowship is supported by the University of Texas at Dallas. The News makes all editorial decisions.

CORRECTION, 9:10AM., Feb. 8, 2022: An earlier version of this story incorrectly said that two milligrams of fentanyl were equivalent to twice the weight of a paperclip. A paperclip weighs about one gram, not one milligram.

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